在患有轻度创伤性脑损伤的退伍军人中,CSF β-粉样蛋白和生物标志物发生变化

Ge Li1, Jeffrey Iliff1, Jane Shofer1

  • 1From the Veterans Affairs Northwest Mental Illness Research, Education, and Clinical Center (MIRECC) (G.L., J.I., J.S., C.L.M., J.M., K.F.P., M.A.R., E.R.P.) and Geriatric Research Education and Clinical Center (GRECC) (G.L., D.C.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; Departments of Psychiatry and Behavioral Sciences (G.L., J.I., J.S., D.C., M.A.R., E.R.P.), Neurology (J.I.), Radiology (C.L.M.), Pharmacology (D.C.), Rehabilitation Medicine (K.F.P.), and Division of Gerontology and Geriatric Medicine Department of Medicine, (D.C.), University of Washington School of Medicine, Seattle, WA; Department of Psychiatry and Neurochemistry (K.B.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, Hong Kong, China; and Wisconsin Alzheimer's Disease Research Center (H.Z.), University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, WI.

Neurology
|March 13, 2024
PubMed
概括

退伍军人的轻度创伤性脑损伤 (mTBI) 可能会增加阿尔茨海默病 (AD) 的风险. 与爆炸相关的mTBI与中年退伍军人的脑脊液Aβ水平降低和认知能力低下有关,这表明潜在的长期AD相关变化.