在患有轻度创伤性脑损伤的退伍军人中,CSF β-粉样蛋白和生物标志物发生变化
Ge Li1, Jeffrey Iliff1, Jane Shofer1
1From the Veterans Affairs Northwest Mental Illness Research, Education, and Clinical Center (MIRECC) (G.L., J.I., J.S., C.L.M., J.M., K.F.P., M.A.R., E.R.P.) and Geriatric Research Education and Clinical Center (GRECC) (G.L., D.C.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; Departments of Psychiatry and Behavioral Sciences (G.L., J.I., J.S., D.C., M.A.R., E.R.P.), Neurology (J.I.), Radiology (C.L.M.), Pharmacology (D.C.), Rehabilitation Medicine (K.F.P.), and Division of Gerontology and Geriatric Medicine Department of Medicine, (D.C.), University of Washington School of Medicine, Seattle, WA; Department of Psychiatry and Neurochemistry (K.B.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, Hong Kong, China; and Wisconsin Alzheimer's Disease Research Center (H.Z.), University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, WI.
退伍军人的轻度创伤性脑损伤 (mTBI) 可能会增加阿尔茨海默病 (AD) 的风险. 与爆炸相关的mTBI与中年退伍军人的脑脊液Aβ水平降低和认知能力低下有关,这表明潜在的长期AD相关变化.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 老年学是指老年学的学科.
背景情况:
- 中度至重度的创伤性脑损伤 (TBI) 与阿尔茨海默病 (AD) 风险增加有关.
- 轻度TBI (mTBI),特别是退伍军人的爆炸相关的mTBI与AD风险之间的关联仍然不太清楚.
- 这项研究使用脑脊液 (CSF) 生物标志物研究了与爆炸相关的mTBI 的退伍军人早期的AD病理变化.
研究的目的:
- 调查与爆炸有关的轻度创伤性脑损伤 (mTBI) 的退伍军人早期阿尔茨海默病 (AD) 变化.
- 为了比较CSFAD生物标志物和退伍军人与没有爆炸相关的mTBI之间的认知表现.
- 评估与爆炸相关的mTBI对AD生物标志物和认知的年龄相关影响.
主要方法:
- 涉及经历mTBI的退伍军人和非mTBI的对照者的横截面病例控制研究.
- 参与者接受了临床和神经心理评估,并进行椎穿刺以收集CSF.
- 通过使用MesoScale发现和INNOTEST ELISA测量了CSF生物标志物 (Aβ40,Aβ42,p-tau181,t-tau).
主要成果:
- 该研究包括51名mTBI和85名非mTBI退伍军人 (平均年龄~33.5岁,99%男性).
- 在CSFAD生物标志物中观察到年龄相关的差异,在年龄较大时最明显.
- 在50岁时,mTBI退伍军人与非mTBI对照者相比,显著降低了CSF Aβ42和Aβ40,以及较差的认知表现 (TMT-B,CVLT-II).
结论:
- 在中年退伍军人中,与爆炸相关的轻度创伤性脑损伤 (mTBI) 与CSF Aβ水平的降低有关.
- 这些发现表明,在爆发性mTBI之后的慢性神经病理过程可能与阿尔茨海默氏症 (AD) 病变发生有相似之处.
- 人们担心,与爆炸有关的mTBI的退伍军人可能会在以后的生活中患上痴呆症的风险增加.
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