在室内灰尘中检测化基,使用新型CP-Seeker数据集成工具
Thomas J McGrath1,2, Julien Saint-Vanne1, Sébastien Hutinet1
1Oniris, INRAE, LABERCA, 44307 Nantes, France.
Analytical chemistry
|March 13, 2024
概括
在来自美国的室内尘埃样本中检测到甲基 (BCA),表明人类潜在的暴露. 需要进一步的研究来了解它们的环境发生和对健康的影响.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 甲基 (BCA) 是阻燃剂,具有类似于持久性有机污染物 (POP) 的潜在环境风险.
- 关于BCA在环境中的存在和人类暴露途径的数据有限,室内灰尘是可疑的途径.
研究的目的:
- 开发和验证一种用于检测和量化室内尘埃中BCA的分析方法.
- 来自六个国家的室内尘埃样本中调查BCA的发生情况.
- 评估通过室内灰尘摄入对BCA的潜在人类暴露.
主要方法:
- 合成BCA-C14混合物标准用于方法验证.
- 增强的液体染色学-电子喷雾电离-轨道探测器-高分辨率质谱仪 (LC-ESI-Orbitrap-HRMS) 与CP-Seeker软件相结合.
- 样品的准备包括超声波提取,酸性清洁和子分成.
主要成果:
- 经过验证的分析方法表明,在尘埃中BCA的回收率 (66-78%) 和精度 (CV ≤10%) 很好.
- 在59个室内尘埃样本中,BCA在7个样本中被检测到,这些样本来自美国.
- 检测到的BCA包括各种碳链长度 (C8-C31) 和化水平 (Br1-4,Br7;Cl2-11),其中BCA-C18最常见.
结论:
- 美国的室内灰尘中存在BCA,这表明潜在的暴露途径.
- 开发的分析方法在环境样本中有效检测BCA.
- 需要对BCA量化,环境分布和健康影响进行进一步的研究.
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