神经血管合和皮质灰质体积在寿命期间之间的负相关性
Peka Christova1,2,3, Lisa M James1,2,3,4, Apostolos P Georgopoulos1,2,3,4,5
1Department of Veterans Affairs Health Care System, The Neuroimaging Research Group, Brain Sciences Center, Minneapolis, Minnesota, United States.
Journal of neurophysiology
|March 13, 2024
概括
静止状态血液氧气水平依赖 (BOLD) 信号周转率 (TBOLD) 随着年龄的增长而大脑体积减少. 这种跨越寿命的反向关系表明慢性神经炎症可能会影响大脑结构和功能.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 衰老研究研究 衰老研究
背景情况:
- 静止状态血液氧气水平依赖 (BOLD) 信号周转率 (TBOLD) 是局部皮质大脑功能的关键指标.
- 了解TBOLD如何随着年龄,性别和大脑体积的变化,对于理解寿命大脑健康至关重要.
研究的目的:
- 在整个生命周期中,在70个皮质区域评估TBOLD.
- 检查健康参与者的TBOLD,大脑体积,年龄和性别之间的关系.
主要方法:
- 利用了来自1344名健康参与者 (8-90岁) 的休息状态功能磁共振成像 (fMRI) 数据.
- 在70个皮质区域分析了TBOLD和皮质灰质体积.
- 研究了与年龄和性别的关联,使用来自人类结合体项目 (HCP) - 发展和HCP-衰老队伍的数据.
主要成果:
- 随着年龄的增长,TBOLD显著增加,而皮质体积随着年龄的增长而减少.
- 在TBOLD和皮质体积之间发现了显著的负相关性,独立于年龄.
- 这种反向关联在几乎所有皮层区域和两性中都是一致的,男性的影响更强烈.
结论:
- 这些发现表明,一个共同的潜在因素,可能是慢性神经炎症,影响了皮质体积减少和整个寿命的TBOLD增加.
- 这种神经炎症可能与重新激活的神经向性病原体有关,随着时间的推移影响大脑结构和功能.
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