棕乙烯胺和聚达丁在儿科刺激性肠综合征:一个多中心随机对照试验
Giovanni Di Nardo1, Luca Bernardo2, Cesare Cremon3
1Sapienza University of Rome, NESMOS Department, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.
Nutrition (Burbank, Los Angeles County, Calif.)
|March 13, 2024
概括
同微缩的棕甲基乙醇胺 (PEA) /聚丁 (PD) 显著减少了患有刺激性肠综合征 (IBS) 的儿童的腹痛. 这种安全有效的治疗方法对IBS-腹亚型具有特别的益处.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 药理学 药理学是指药理学的学科.
- 临床试验研究 临床试验研究
背景情况:
- 刺激性肠综合征 (IBS) 是儿童常见的功能性胃肠疾病.
- 腹痛是儿科IBS的主要症状,严重影响生活质量.
- 目前对儿科IBS症状的治疗选择有限.
研究的目的:
- 评估联合微缩的棕甲基乙醇胺 (PEA) /聚达丁 (PD) 治疗儿科IBS患者腹痛的疗效和安全性.
- 在双盲,随机对照试验中,将共微化PEA/PD与安慰剂的结果进行比较.
主要方法:
- 一个多中心,双盲,安慰剂控制,并行手臂试验,涉及70名儿科IBS患者 (年龄10-17岁).
- 参与者在12周内每天三次接受共微缩PEA/PD或安慰剂.
- 评估的结果包括IBS-严重性评分系统 (IBS-SSS),腹痛频率和便一致性 (布里斯托尔便量表).
主要成果:
- 与安慰剂 (P = 0.015) 相比,在联合微缩的PEA/PD组中,显著更多的患者实现了完全缓解 (IBS-SSS <75).
- 治疗组的腹痛强度和频率显著降低.
- 在IBS-腹亚型 (P = 0.01) 的患者中观察到特别的益处.
结论:
- 同微缩PEA/PD是一种安全有效的治疗选择,用于治疗儿科IBS的腹痛.
- 这项研究支持使用共微化PEA/PD来改善儿童的IBS症状.
- 没有报告任何不良事件,突出显示了治疗的安全性.
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