,和是耐药高血压的危险因素吗?
Arturo Corbatón Anchuelo1, Nieves Martell Claros2, María Abad Cardiel3
1Vascular risk group, Health Research Institute of the San Carlos Clinical Hospital (IdISSC), Madrid, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain; Hypertension and Vascular Risk Unit, Internal Medicine Service, San Carlos Clinical Hospital, Madrid, Spain.
概括
血中 (Pb) 含量升高,特别是超过5.55μg/dL,与显著更高的抗性高血压 (rHT) 风险有关. (Cd) 和 (Hg) 与这种情况的关联较小.
科学领域:
- 环境健康 环境健康
- 心血管医学 心血管医学
- 毒理学 毒理学 毒理学
背景情况:
- (Pb), (Cd) 和 (Hg) 等有毒微量元素是公认的公共卫生问题.
- 这些因素是心血管疾病和高血压 (HT) 的风险因素,可能导致抗性高血压 (rHT).
研究的目的:
- 为了比较抗性和非抗性HT的个体中的Pb,Cd和Hg的血度.
- 为了确定有毒元素水平和rHT的发展之间的关系.
主要方法:
- 一项涉及73名年龄在21至80岁,体重指数<40 kg/m2的受试者的横截面研究.
- 使用电热原子吸收光谱法测量了Cd,Pb和Hg的血液度.
- 抗性高血压是根据美国心脏协会 (AHA) 的标准来定义的.
主要成果:
- 在46名具有rHT的受试者中,血液Pb水平在HT和rHT组之间没有显著差异 (中位数为3.9比3.6μg/dL,p=0.941).
- 同样,血液中的Cd (中位数为0.07比0.30μg/L,p=0.681) 和Hg (中位数为7.9比7.3μg/L,p=0.611) 水平也没有显著差异.
- 后勤回归表明,较高的Pb水平 (≥5.55μg/dL) 与增加的rHT风险 (OR=3.44,p=0.086) 之间存在关联,特别是在非肥胖男性中 (OR=9,p=0.029).
- 较高的Cd水平 (≥0.75μg/L) 与男性 (p=0.076) 和吸烟者 (ORa 12.6,p=0.072) 的高rHT风险有关.
结论:
- 较高的血水平 (≥5.55μg/dL) 与抗性高血压的风险增加有关.
- 与相比,和与耐性高血压的关联较小.
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