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嗅觉值作为多发性硬化症长期复发活动的生物标志物
Klaus Berek1, Harald Hegen1, Michael Auer1
1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Multiple sclerosis and related disorders
|March 13, 2024
概括
嗅觉值 (OT) 可以预测多发性硬化症 (MS) 疾病的长期发展过程. 较高的OT分数表明复发和残疾恶化的风险较低,这表明OT是炎症活动的标志物.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 嗅觉值 (OT) 被认为是多发性硬化症 (MS) 短期炎症活动的标志物.
- 对于MS的长期临床疾病过程中,OT的预测价值尚未完全阐明.
研究的目的:
- 研究嗅觉值 (OT) 作为多发性硬化症 (MS) 长期临床疾病过程的预测因素的潜力.
- 为了确定OT是否可以预测疾病进展,复发率和治疗反应在六年内.
主要方法:
- 一项前性纵向研究跟踪了139名多发性硬化患者6年,每两年进行一次临床评估.
- 使用嗅觉值 (OT) 测试使用嗅觉值 (OT) 测试.
- 嗅着棒子的鼻子.
- 测试是在基线和1,2,6年进行的.
- 评估了扩展残疾状态量表 (EDSS) 的得分,复发发生率和认知功能 (符号数字模式测试).
主要成果:
- 较高的嗅觉值 (OT) 在基线和随访时的得分与复发风险降低相关 (HR:0.65-0.92) 和EDSS恶化 (HR:0.86-0.89).
- 在需要升级疾病修饰治疗 (DMT) 的患者中观察到较低的OT得分.
- 在OT和不依赖复发活动 (PIRA) 或认知恶化的进展之间没有发现显著的关联.
结论:
- 嗅觉值 (OT) 显示出作为预测多发性硬化症 (MS) 长期炎症性疾病活动的替代标记物的潜力.
- 在MS患者中,OT也可以作为疾病修饰治疗 (DMT) 失败的指标.
相关概念视频
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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
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