评估精油在一种新的双层输送系统中封装的低脂效应
Xueli Zhang1, Xu Guo2, Jinyue Sun2
1College of Food Science and Engineering, Shandong Agricultural University, Taian 271018, PR China; Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro-Products Processing Technology of Shandong Province, Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences, 23788 Gongye North Road, Jinan 250100, PR China.
这项研究开发了一种新的大精油输送系统 (GEO-DCL),可以提高生物可用性和稳定性. 新系统有效降低血脂水平,改善小鼠的脂质不良症,为功能性食物铺平了道路.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物技术是生物技术.
- 营养保健品 营养保健品
背景情况:
- 大精油 (GEO) 由于味道,溶解度和生物可用性差,使用范围有限.
- 脂质体和β-cyclopodextrin提供了稳定性,气味掩盖和改善生物利用性的解决方案.
研究的目的:
- 设计和准备一个双层的GEO β-环极素包容化合物脂质体 (GEO-DCL) 输送系统.
- 评估GEO-DCLs的增强性质和体内降脂效应.
- 探索GEO-DCL在功能性食品应用中的潜力.
主要方法:
- 准备GEO-DCL并与GEO脂质体 (GEO-CLs) 进行比较.
- 在体外评估封装效率和释放动力学.
- 在活体中对高胆固醇血症小鼠进行研究,以评估对血脂,体重,脂肪沉积和肝脏健康的影响.
主要成果:
- 与GEO-CL相比,GEO-DCL表现出更高的封装效率 (>88%) 和更低的GEO释放率 (40%的减少).
- 在高胆固醇血症小鼠中,GEO-DCL治疗显著降低了体重,脂肪沉积,TC,LDL-C和肝损伤.
- 观察到剂量依赖的降脂效应,改善了HDL-C水平和抑制了脂肪细胞生长.
结论:
- GEO-DCL有效地提高了GEO的生物可用性和稳定性,提供了卓越的降脂效果.
- 开发的系统有望应用于功能性食品,例如复合石榴汁饮料.
- 这项研究为利用GEO在功能性食品开发中用于管理脱脂症提供了基础.
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