ERCC1和XPC多态性和对头癌的易感性之间的关系:系统性审查,元分析和试验顺序分析
Mohammad Moslem Imani1, Sattar Akbari1, Majid Shalchi2
1Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Archives of oral biology
|March 13, 2024
概括
这一元分析将ERCC1 rs2228000 T等位基因和TT基因型与增加头癌 (HNC) 风险联系起来. 其他ERCC1和XPC多态没有与HNC显著关联.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 在瘤学瘤学.
- 分子流行病学分子流行病学
背景情况:
- 头癌 (HNC) 是一个重要的全球健康问题.
- 遗传变异,特别是像ERCC1和XPC这样的DNA修复基因,可能会影响HNC易感性.
- 了解这些遗传关联对于风险分层和有针对性的预防策略至关重要.
研究的目的:
- 进行全面的元分析,调查ERCC1和XPC多态化与头癌 (HNC) 风险之间的关联.
- 纳入额外的研究和进行进一步的分析,以完善对这些遗传关联的理解.
- 通过各种遗传模型评估特定多态度 (rs2228000,rs11615,rs3212986,rs735482,rs2228001,PAT) 对HNC风险的影响.
主要方法:
- 在主要数据库 (PubMed/Medline,科学网,Scopus,Cochrane图书馆) 进行了详尽的文献搜索,截至2023年11月18日.
- 确定并包括了与HNC风险有关的ERCC1和XPC多态性研究的相关研究.
- 使用Review Manager 5.3软件计算效果大小,以95%置信区间 (CI) 的几率比率 (OR) 呈现.
主要成果:
- 在ERCC1 rs2228000多态的T等位基因中观察到一个统计学上显著的关联 (OR = 1.11; p = 0.02; 95%CI: 1.02, 1.22).
- 在rs2228000的TT基因型中,在同卵性 (OR=1.61;p=0.02;95%CI:1.07,2.42) 和衰退型模型 (OR=1.53;p=0.02;95%CI:1.06,2.22) 中也显示出显著的关联.
- 在任何遗传模型中,对于其他研究的多态 (rs11615,rs3212986,rs735482,rs2228001,PAT) 没有发现显著的关联.
结论:
- 分析证实ERCC1 rs2228000 T等位基因和TT基因型之间存在显著的关联,并增加了头癌的风险.
- 对于其他评估的ERCC1和XPC多态与HNC风险,没有发现显著的关联.
- 诸如种族,癌症亚型和控制源等因素可能会影响观察到的遗传关联,突出显示了对HNC的遗传贡献的复杂性.
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