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一个可编程的向蛋白质降解平台,用于哺乳动物细胞和小鼠中的多功能应用

Xiaoding Ma1, Jianli Yin2, Longliang Qiao1

  • 1Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Centre, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.

Molecular cell
|March 13, 2024
PubMed
概括

研究人员开发了新的向蛋白质降解 (TPD) 系统,使用修改后的Trim21 (ΔTrim21) 精确控制蛋白质水平. 这些基于 ΔTrim21 的系统在细胞和动物中提供可编程的化学和光触发应用.

关键词:
案件9/d案件9切割-远离的时间化学遗传学 化学遗传学可控制的目标蛋白质降解降解.基因工程是基因工程,是基因工程.视觉遗传学 视觉遗传学瘤治疗的治疗方法

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