免疫细胞转录组是通过维生素D补充剂调节的3在参加随机的安慰剂对照试验的第一次脱髓化事件的人群中
Wei Zhen Yeh1, Melissa Gresle1, Rodney Lea2
1Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.
Clinical immunology (Orlando, Fla.)
|March 13, 2024
概括
维生素D3补充剂调节了免疫细胞基因表达在第一次脱髓化事件的个体. 高剂量的维生素D3诱导了抗炎性基因特征,这表明它可能在治疗多发性硬化症方面发挥作用.
科学领域:
- 神经免疫学 神经免疫学
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 维生素D缺乏是发展多发性硬化症 (MS) 的已知危险因素.
- 在PrevANZ试验中,研究了维生素D3补充剂用于预防第一个脱髓化事件后的疾病活动.
研究的目的:
- 为了检查维生素D3补充剂对外周免疫细胞基因表达的影响.
- 为了确定维生素D3对免疫转录组的剂量依赖作用.
主要方法:
- 55名参与者参与的PrevANZ试验的子研究.
- 随机分配到安慰剂或每日维生素D3剂量 (1000,5000或10,000 IU).
- 周围血液RNA测序在基线和12周.
主要成果:
- 高剂量的维生素D3调节了外围免疫细胞的基因表达.
- 抗原呈现和病毒反应途径的升级.
- 氧化酸化和关键免疫信号通路 (TNF-α,IL-17) 的下调.
结论:
- 12周的维生素D3补充剂改变了周围免疫细胞转录组.
- 对免疫基因表达特征的剂量依赖性影响的证据.
- 诱导抗炎基因表达支持维生素D在神经炎症中的作用.
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