在BCG疫苗接种后,阿伦德罗纳酸在健康的年轻人中调节细胞因子反应
Ozlem Bulut1, Gizem Kilic1, Priya A Debisarun1
1Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Immunology letters
|March 13, 2024
概括
含双酸盐 (N-BPs),如阿伦德罗纳特,可以降低Bacillus Calmette-Guérin (BCG) 疫苗接种引起的训练免疫力. 这种由N-BPs进行的免疫调节会影响细胞因子的产生和免疫细胞的反应.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢途径 代谢途径
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 巴塞勒斯卡尔梅特 - 格林 (BCG) 疫苗接种诱导了天生的免疫细胞中训练的免疫力.
- 通过美瓦酸盐的胆固醇合成,增强了训练的免疫力.
- 含的双酸盐 (N-BPs) 抑制胆固醇的合成.
研究的目的:
- 调查N-BPs对BCG诱导的训练免疫的影响.
- 评估阿伦德罗纳酸对BCG疫苗接种后免疫细胞群和细胞因子概况的影响.
主要方法:
- 一个安慰剂控制的临床研究,涉及年轻,健康的个体.
- 在BCG疫苗接种当天服用单次口服阿伦德罗纳酸剂.
- 治疗后一个月,对周围血液单核细胞 (PBMCs) 免疫细胞数量,血细胞和细胞因子产生的分析.
主要成果:
- 在BCG接种疫苗后一个月,阿伦德罗纳酸治疗增加了中性粒细胞和血细胞的数量.
- 阿伦德罗纳酸降低了通过使用细菌和病毒抗原刺激的PBMCs产生的益炎性细胞因子的产生.
- 阿伦德罗纳特在PBMC中转录性抑制了免疫反应途径.
结论:
- 以阿伦德罗纳酸为例的N-BPs调节了BCG疫苗接种的长期影响.
- 阿伦德罗纳酸会影响先天免疫细胞的细胞因子生产能力,这表明它在训练免疫调节中的作用.
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