微血管负担和中风和痴呆的长期风险在2型糖尿病中
Yu-Jie Liu1, Jun-Yu Zhao2, Wen-Wen Han1
1Department of Nutrition and Food Hygiene, MOE Key Laboratory of Geriatric Diseases and Immunology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Journal of affective disorders
|March 13, 2024
概括
微血管疾病 (MVD) 在2型糖尿病患者中显著增加中风和痴呆的风险. 包括视网膜病变,神经病变和病在内的MVD疾病的数量与更高的事件率直接相关.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
背景情况:
- 2型糖尿病 (T2DM) 是心血管和神经系统并发症的主要危险因素.
- 微血管疾病 (MVD) 包括诸如视网膜病变,外围神经病变和慢性病等情况,这些都是T2DM中常见的.
- 在T2DM患者中,MVD负担对中风和痴呆风险的影响需要进一步阐明.
研究的目的:
- 调查微血管疾病 (MVD) 负担与2型糖尿病 (T2DM) 患者中风和痴呆风险之间的关联.
- 分析单个MVD条件 (视网膜病变,外围神经病变,慢性病) 对中风和痴呆风险的具体贡献.
主要方法:
- 利用了来自26173名T2DM参与者的英国生物库数据,没有先前的中风或痴呆症.
- 使用视网膜病变,外围神经病变和慢性病的存在来评估MVD负担.
- 采用考克斯回归模型计算中风和与MVD相关的痴呆的危险比率.
主要成果:
- 超过11.5年,增加的MVD与中风 (所有亚型) 和痴呆症 (所有亚型) 的风险更高相关 (P趋势<0.001).
- 患有三种MVD疾病的个体面临显著增加的风险:所有中风5.03,所有痴呆4.28.
- 慢性病与中风的联系最强,而外围神经病变与痴呆症亚型最为相关.
结论:
- 越来越多的微血管疾病状况在T2DM患者中显著增加了中风和痴呆的风险.
- 特定类型的MVD会影响不同类型的中风和痴呆的风险概况.
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