儿童肥胖对神经病症和主观福祉的因果影响:一项两样本的门德尔随机化研究
Hao Gou1, Li Liu2, Xiangjuan Sun1
1Department of Pediatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610000, Sichuan Province, China.
Journal of affective disorders
|March 13, 2024
概括
较高的儿童BMI因果上增加了神经病症,并降低了主观幸福感 (SWB). 神经病症部分调解了这种关系,这表明体重管理可以改善人格和SWB.
科学领域:
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 儿童肥胖是一个日益关注的问题,与心理因素的潜在联系.
- 儿童身体质量指数 (BMI),神经病症和主观幸福感 (SWB) 之间的因果关系尚不清楚.
- 了解这些联系对于开发有效的干预措施至关重要.
研究的目的:
- 用孟德尔随机化研究儿童BMI对神经病症和SWB的因果关系.
- 探索神经病症在儿童BMI和SWB之间的关系中的潜在调解作用.
主要方法:
- 两个样本的门德尔随机化 (MR) 分析利用了大规模的全基因组关联研究 (GWAS) 总结统计数据.
- 研究了儿童BMI (n=39,620) 对神经病症 (n=366,301) 和SWB (n=298,420) 的因果关系.
- 采用逆变量加权 (IVW),加权模式,中位数,MR-Egger和中介分析.
主要成果:
- 基因预测的儿童高BMI与增加的神经病症 (β=0.045,p=0.006) 和减少SWB (β=-0.059,p=0.0009) 有因果关系.
- 灵敏度分析证实没有显著的异质性或水平性.
- 神经病症部分调解了童年BMI对SWB的因果作用 (21.3%的调解).
结论:
- 较高的儿童BMI对增加的神经病症和减少SWB有直接的因果影响.
- 神经病症作为从童年BMI到SWB的途径中的部分调解者.
- 进一步研究分子机制和体重管理改善人格和SWB的潜力是有必要的.
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