在抑郁和焦虑中隐含情绪调节的共享和独特的前额叶皮层改变:fNIRS调查
Hai-Yang Wang1, Hui-Li You2, Chun-Li Song2
1Department of Neurology and Psychiatry, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China; Department of Neurology, Jining No. 1 People's Hospital, Jining 272000, China.
Journal of affective disorders
|March 13, 2024
概括
这项研究揭示了主要抑郁症 (MDD) 和泛性焦虑症 (GAD) 在隐性情绪调节期间都显示了脊侧前额皮层 (DLPFC) 和轨道前额皮层 (OFC) 激活的减少,每个疾病都有不同的OFC模式.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 情绪调节缺陷,特别是认知重新评估,是抑郁症和焦虑症的核心原因.
- 隐性情绪调节的神经机制研究不足,在这些障碍中不清楚共享或独特的途径.
研究的目的:
- 研究主要抑郁症 (MDD),泛性焦虑症 (GAD) 和健康对照 (HC) 中隐性认知再评估的神经机制.
- 确定MDD和GAD情绪调节的共同和独特的神经基础.
主要方法:
- 利用功能近红外光谱 (fNIRS) 在隐性认知重新评估任务期间检查大脑活动.
- 包括28名MDD患者,25名GAD患者和30名HC参与者,以及神经心理和临床评估.
主要成果:
- 与HC相比,MDD和GAD组在背侧前额皮质 (DLPFC) 和轨道前额皮质 (OFC) 中的激活减少.
- 患有MDD的患者表现出较低的认知重新评估使用和反思,而GAD患者使用的视角更少.
- 观察到明显的OFC激活模式:MDD中的不充分激活和GAD中的失活,与临床严重程度和策略使用相关.
结论:
- 这项fNIRS研究是第一个确定抑郁和焦虑中隐性情绪调节的共享和独特的神经生物学特征的研究.
- 减少DLPFC/OFC激活在情绪调节障碍中具有重要意义,独特的OFC模式区分MDD和GAD.
- 这些发现表明认知行为疗法和神经调节技术的潜在治疗点.
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