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开发基于乳酸的链延长剂和豆油衍生的聚氨,用于环保的持续药物输送系统

Amer Iqbal¹, Muhammad Asif Javaid¹, Muhammad Tahir Hussain¹

¹Department of Applied Sciences, National Textile University, Faisalabad-37610, Pakistan.

International journal of biological macromolecules

|March 13, 2024

概括

来自大豆油的新生物降解型聚氨对药物输送有希望. 研究人员发现,随着这些可持续材料中的聚乙烯糖醇含量增加,药物释放量减少.

科学领域:

材料科学材料科学材料科学
聚合物化学聚合物化学
生物医学工程生物医学工程

背景情况:

开发可持续,生物相容和生物降解的聚合物对于先进的应用至关重要.
聚氨具有多功能性质,但通常依赖于不可再生资源.
生物基聚合物为聚氨合成提供了一个可持续的替代品.

研究的目的:

使用生物基聚醇和聚乙烯糖醇 (PEG) 合成和表征新型聚氨 (PU-1至PU-4).
评估这些合成聚氨作为药物输送系统的潜力.
研究PEG含量对药物释放特性的影响.

主要方法:

聚氨合成使用来自大豆油的生物基聚,PEG和异二酸盐.
通过SEM,FTIR和NMR光谱学进行表征 (H和C).
使用加巴丁通过溶剂蒸发加载的药物输送研究,释放监测在0.06 N HCl.

主要成果:

合成的聚氨 (PU-1至PU-4) 已经成功地得到了特征.
样本PU-P1在6小时后表现出最大的 gabapentin 释放率为53.0%.
药物释放率随着聚氨基基质中聚乙烯甘醇含量增加而降低.

结论:

合成的聚氨是可持续的,生物相容的和生物降解的.
这些材料显示出控制药物输送应用的潜力.
聚乙烯甘醇含量显著影响药物释放动力学,为配方提供可调节的参数.

关键词:

药物输送系统是药物输送系统.牛奶酸是什么牛奶酸是什么聚氨是一种聚氨.大豆油是大豆油中的一种.

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