海马体和前额叶皮质的结构功能相互作用与健康衰老中的情节性记忆有关
Jamie Snytte1, Roni Setton2, Laetitia Mwilambwe-Tshilobo3,4
1Department of Psychology, McGill University, Montreal, Quebec H3A 1G1, Canada jamie.snytte@mail.mcgill.ca nathan.spreng@gmail.com.
eNeuro
|March 13, 2024
概括
健康的衰老通过大脑网络重组来保护记忆. 海马和前额叶皮质的结构完整性和功能连接性增加,支持老年人更好的记忆性能.
科学领域:
- 神经科学是一个神经科学.
- 认知老龄化 认知老龄化
- 神经成像是一种神经成像.
背景情况:
- 情节性记忆随着年龄的增长而下降,这与海马和侧面前额皮层的变化有关.
- 以前的研究经常独立研究与记忆有关的结构和功能性大脑变化.
- 了解大脑结构和功能之间的相互作用对于解释老化中的记忆性能至关重要.
研究的目的:
- 研究结构完整性和功能连接性之间的相互作用如何与健康衰老中的情节性记忆有关.
- 探索与年龄相关的记忆补偿背后的神经机制.
- 检查年轻人和老年人之间与记忆相关的大脑网络的差异.
主要方法:
- 结构性MRI和多声波静止状态fMRI数据的多模式,多变量分析.
- 包括年轻的 (N=111) 和年长的 (N=78) 成年参与者.
- 使用列表回忆,关联记忆和源记忆任务评估情节性记忆.
主要成果:
- 后部海马体和中部前回形中较大的结构完整性与增加的网络内连接性相关.
- 这种结构完整性和连接性的模式与老年人更好的关联性和源记忆有关.
- 具有功能重组 (切割连接) 的老年人表现出更好的记忆力,尽管海马体积减少.
结论:
- 功能重组,以削减连接为特征,有助于健康衰老中的记忆补偿.
- 在老年人中,更好的情节性记忆与海马和前额叶皮层的结构完整性有关.
- 这些发现凸显了大脑网络相互作用在老化期间维持认知功能的重要性.
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