在多个膀癌亚型分类分类器中对分子亚型的对齐
Moritz J Reike1, Joep J de Jong2, Tarek A Bismar3
1Department of Urologic Sciences, University of British Columbia, Vancouver, Canada; Department of Urology, Marien Hospital Herne, Ruhr-University Bochum, Herne, Germany.
Urologic oncology
|March 13, 2024
概括
肌肉侵入性膀癌 (MIBC) 中的光样分子亚型不会从新辅助化疗 (NAC) 中受益. 这些发现突出了不同分类器的分子亚型命名体系的不一致性.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 分子生物学分子生物学
背景情况:
- 肌肉侵入性膀癌 (MIBC) 治疗包括新辅助化疗 (NAC),随后是激进囊切除术 (RC).
- 在NAC和RC之后,MIBC的分子亚型与患者的治疗结果有着不一致的关联.
研究的目的:
- 评估各种分类器的分子亚型与接受RC的MIBC患者的整体存活率 (OS) 之间的关联.
- 在不同分类系统中评估分子亚型命名体系的一致性.
主要方法:
- 来自MIBC患者的NACmeta元队列 (N=601) 的基因表达数据的分析.
- 使用基因组亚型分类器 (GSC),共识分类器,TCGA分类器和隆德分类器分配分子亚型.
- 逆概率权重用于生存分析,以平衡NAC和非NAC组.
主要成果:
- 观察到光线类亚型 (GSC-Luminal,共识-光线 papillary,TCGA光线 papillary,Lund-UroA) 的高一致性.
- 无论NAC治疗如何,在患有光样亚型的患者中,在3年后的生存期中没有显著差异.
- 在不同分类器的基础类型亚型分类和命名法中发现的不一致性.
结论:
- 类似于光的分子亚型识别MIBC患者不太可能从当前的NAC疗法中受益,即使是在局部发达的疾病中.
- 在分类命名法中的差异并不总是反映了潜在的生物学区别.
- 分子亚型的标准化对于一致的临床应用和治疗分层至关重要.
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