后COVID帕金森症:一个范围审查
Paola Polverino1, Antoniangela Cocco1, Alberto Albanese2
1Department of Neurology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Parkinsonism & related disorders
|March 13, 2024
概括
后COVID帕金森症以各种方式呈现,不复杂的COVID-19更常与没有脑病变的帕金森病 (PD) 相联系. COVID-19可能是巧合,但不同的帕金森症子集表明SARS-CoV-2的潜在作用.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 缺乏COVID后帕金森症的临床特征和结果的系统组织.
- COVID-19和帕金森症之间的相关性需要阐明.
研究的目的:
- 系统地审查和组织COVID后帕金森症的临床特征和结果.
- 为了调查COVID-19和帕金森症之间的潜在相关性.
主要方法:
- 对已发表的COVID后帕金森症病例进行范围审查.
- 在PubMed和Embase数据库中进行了搜索.
- 提取并客观评估患者数据,临床特征,诊断和结果.
主要成果:
- 在17篇出版物中分析了26例病例,确定了三个综合征:典型的帕金森运动综合征,与姿势不稳定和步态障碍相关的帕金森症,以及与帕金森症相关的脑病变.
- 诊断包括帕金森病 (PD),可能的PD,可能的多系统缩,获得的帕金森症和未分类的帕金森症.
- 没有并发症的COVID-19与PD更相关,而与帕金森症的脑病变发生在COVID-19严重程度的范围内.
结论:
- 没有并发症的COVID-19患者可能出现PD和无脑病变;COVID-19的致病作用尚未证明,可能是巧合.
- 与帕金森症相关的脑病变代表着一个独特的子集,这表明SARS-CoV-2感染的潜在不同的病原作用.
- 这些发现为未来研究COVID后神经系统后果提供了基础.
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