在患有血液性恶性瘤的患者中,COVID-19的临床表现和风险因素及其严重程度
Tzong-Yow Wu1, Wan-Ting Tsai2, Kai-Hsiang Chen3
1Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
概括
患有血液性恶性瘤的患者面临严重的COVID-19结果. 异性干细胞移植,糖尿病和淋巴缺血增加死亡风险,而疫苗接种提供了保护.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 患有血液性恶性瘤 (HM) 的患者面临2019年冠状病毒严重疾病 (COVID-19) 的高风险.
- 评估COVID-19住院的HM患者的临床结果至关重要.
研究的目的:
- 为了评估COVID-19在患有血液性恶性瘤的住院患者的临床结果.
- 为了确定与这种患者群体中严重疾病进展和脱离隔离相关的因素.
主要方法:
- 对实验室确诊的COVID-19住院的成人HM患者的回顾性分析 (2021年5月 - 2022年11月).
- 主要结局:需要机械通风的呼吸衰竭或60天死亡率.
- 二次分析:与28天内脱离隔离相关的因素.
主要成果:
- 在152名患者中,14.5%的患者在60天内出现呼吸衰竭或死亡.
- 严重结局的危险因素包括全源造血干细胞移植 (allo-HSCT),2型糖尿病,淋巴缺血和<2个SARS-CoV-2疫苗剂量.
- 65.1%的人在28天内实现了脱隔离;B细胞枯竭疗法和淋巴衰竭与延迟脱隔离有关.
结论:
- 血液性恶性瘤患者的呼吸系统衰竭和死因SARS-CoV-2感染的死亡率很高.
- 艾洛-HSCT,2型糖尿病和入院淋巴缺血是不良结果的关键风险因素.
- 接收至少两次疫苗剂量显著保护免受严重的COVID-19进展.
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