在2017年和2018年在日本的常规免疫接种中,幼儿园爆发了麻疹疫情,以及疫苗的有效性
Tomoko Sakaue1, Tamie Sugawara2, Kyoko Mukasa3
1Kusabue Nursery School, Tokyo, Japan.
Vaccine
|March 13, 2024
概括
在日本一所幼儿园爆发的疫情中,常规的两剂疫苗接种显示了低的疫苗有效性 (VE) 对感染. 然而,疫苗接种显著降低了疾病的严重程度,这表明除了预防初始感染之外还有好处.
科学领域:
- 儿童传染病 儿童传染病
- 疫苗学 疫苗学 疫苗学
- 公共卫生监督是对公共卫生的监督.
背景情况:
- 日本于2014年10月为1岁儿童推出了常规的两剂疫免疫接种.
- 这项研究调查了根据新的常规免疫政策在幼儿园环境下爆发的水疫情.
- 研究了水免疫的有效性和严重性.
研究的目的:
- 报告幼儿园和周边地区在常规免疫接种下爆发的水疫情.
- 为了测量常规的两剂水免疫接种对感染发病的有效性.
- 在幼儿园学校环境中评估水的严重程度.
主要方法:
- 观察性研究分析疫苗有效性 (VE) 和严重程度.
- 2017年4月至2018年3月,从幼儿园和周边教育机构 (城市A) 收集的数据.
- 严重程度以幼儿园缺席的时间来定义;使用费舍尔的精确测试和线性回归来评估VE.
主要成果:
- 在研究期间,在幼儿园,小学和初中观察到水病例.
- 疫苗对感染的有效性 (VE) 在所有年龄段为48.1%,在3岁以上为49.2%,但不具有统计学意义.
- 接种一剂或多剂的疫苗显著降低了天花的严重程度.
结论:
- 在幼儿园观察到低且不显著的VE抗感染,即使接种了两剂疫苗.
- 虽然VE的严重程度在多剂量时得到证实,但第二剂量似乎与单剂量相比没有提供额外的严重程度降低.
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