ангиотензин II 参与胺诱导敏感化的发展和持续:干多巴胺再吸收影响
Osvaldo M Basmadjian1, Victoria B Occhieppo1, Antonella E Montemerlo2
1Instituto de Farmacología Experimental de Córdoba (IFEC-CONICET), Departamento de Farmacología Otto Orsingher, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
The European journal of neuroscience
|March 13, 2024
概括
大脑 ангиотензин II 的作用.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 成研究 研究成研究
背景情况:
- 氨基胺 (AMPH) 导致行为和神经化学敏感性,其特点是超位运动和多巴胺释放的增加.
- 大脑 ангиотензинII通过AT1受体 (AT1-R) 作用,积极调节多巴胺释放.
- 在AMPH诱导的敏感化和多巴胺再吸收中AT1-R的作用尚未完全阐明.
研究的目的:
- 调查AT1-R在AMPH诱导的敏感性发展和维持中的作用.
- 分析AT1-R在条纹性多巴胺重新吸收中的参与.
- 探索AT-R作为多巴胺相关疾病的潜在治疗标.
主要方法:
- 动物每天接受AMPH给药5天,敏感性评估在戒药后21天.
- 在AMPH暴露之前或之后,AT1-R抗剂坎德沙坦被使用.
- 使用了运动活动,c-Fos免疫染,多巴胺再吸收动力学和社会相互作用测试.
主要成果:
- 重复暴露于AMPH引起了敏感性,这种敏感性被坎德沙坦治疗预防和逆转.
- AT1-R阻塞增强了多巴胺再吸收动力学.
- 无论是AMPH还是AT1-R封锁都没有影响社会互动.
结论:
- AT1-R在AMPH诱导的敏感性发展和维持中发挥着至关重要的作用.
- 通过AT1-R阻断增强多巴胺再吸收动力学可能会减弱AMPH敏感性.
- AT1R对抗是一种有前途的治疗策略,用于多巴胺失衡相关的疾病,如成和精神分裂症.
相关概念视频
01:25Adrenergic Agonists: Indirect-Acting Agents
1.6K
Indirect-acting adrenergic agonists potentiate the effects of endogenous catecholamines through different mechanisms without directly binding to adrenoceptors.
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
1.6K
01:21Drugs Affecting Neurotransmitter Release or Uptake
1.1K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.1K
01:29Drugs Affecting Neurotransmitter Synthesis
1.4K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.4K
01:16Adrenergic Agonists: Chemistry and Structure-Activity Relationship
3.0K
Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
3.0K
01:23Drugs Acting on Autonomic Ganglia: Stimulants
1.3K
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
1.3K
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
192
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
192