副心脏脂肪组织对心脏功能和形态的影响在患有透静功能障碍的患者中
Alexander Schulz1,2, Sören J Backhaus3, Torben Lange1,2
1Department of Cardiology and Pneumology, University Medical Center Göttingen, Georg August University of Göttingen, Göttingen, Germany.
ESC heart failure
|March 13, 2024
概括
腹筋功能障碍患者心上脂肪组织 (EAT) 的增加与心脏功能恶化和结构变化有关. 高EAT特异性损害心房功能,有助于心脏衰竭与保存的喷射分数 (HFpEF).
科学领域:
- 心脏病学 心脏病学
- 心脏成像 - - 心脏成像
- 心脏衰竭研究研究
背景情况:
- 扩张性功能障碍是心力衰竭的关键特征,具有保存的射出分数 (HFpEF).
- 副心脏脂肪组织 (EAT) 是代谢活跃的,可能会影响心脏功能.
- 在透支功能障碍中,EAT体积和分布对心脏功能的特定影响需要进一步阐明.
研究的目的:
- 调查心表脂肪组织 (EAT) 体积增加及其区域分布对心脏功能在患有透支功能障碍的患者的影响.
- 评估EAT和心肌变形之间的关联,以及不良重塑的标志物.
主要方法:
- 68名患有透支功能障碍和保留喷射分数的患者接受了心脏磁共振 (CMR),心声回声和右心脏导管.
- 使用CMR量化了EAT的数量.
- 使用多变量回归分析来评估EAT与心脏功能和重塑的关联.
主要成果:
- 患有高EAT的患者表现出更高的HFpEF得分,脑内尿素水平的N终端前激素升高,并更频繁地诊断出明显的HFpEF.
- 高EAT与不利的结构改造有关,CMR上的T1倍更高表明了这一点.
- 患有高EAT的患者在休息和运动期间表现出心房张力受损,在运动压力期间表现出心室张力受损.
结论:
- 腹功能障碍患者的EAT增加与更明显的腹功能衰竭和不利的结构重塑有关.
- 尽管形态相似,但高EAT显著损害心脏功能,特别是在心房.
- 区域性增加的EAT似乎直接诱导心房功能衰竭,这是HFpEF的一个明显的病理生理特征.
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