在受伤后的肺炎后,肠道病生物体的急性出现
Jennifer A Munley1, Lauren S Kelly, Gwoncheol Park
1From the Department of Surgery (J.A.M., L.S.K., S.K.D., G.S.G., P.S.C., K.B.K., L.E.B., P.A.E., A.M.M.), Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville; and Department of Nutrition and Integrative Physiology (G.P., R.N.), Florida State University, Tallahassee, Florida.
The journal of trauma and acute care surgery
|March 14, 2024
概括
严重的伤害和败血症会大大改变肠道微生物群,导致有益细菌的大量丧失和有害病原体的生长. 病生物组的这些变化是男性和女性的性别特异性.
科学领域:
- 微生物学 微生物学
- 创伤研究 创伤研究
- 免疫学 免疫学 免疫学
背景情况:
- 以前的研究表明,在创伤或败血症后,肠道微生物组的性别特异性变化.
- 宿主性别对继综合性伤害后败血症后的失生症的影响尚不清楚.
研究的目的:
- 为了研究多分支创伤和随后的肺炎后肠道微生物组的性别特异性变化.
主要方法:
- 雄性和雌性大鼠经历了创伤 (PT),有或没有束压力 (RS) 和肺炎 (PNA).
- 便微生物组分析使用16SrRNA测序和生物信息学.
- 评估了微生物多样性 (α-和β-多样性).
主要成果:
- 所有受伤组都显示微生物多样性减少 (Chao1指数).
- 与未感染创伤组相比,败血症 (PT-PNA,PT/RS-PNA) 改变了微生物组成和β-多样性.
- 在第二天,在PT-PNA组中观察到微生物组合的性别特异性差异,男性和女性的细菌丰度明显.
结论:
- 败血症的多部门创伤会导致显著的肠道失调,性别会影响微生物的改变.
- 这些特定于性别的病生物组变化可能会影响严重创伤和败血症后的结果.
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