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清晰细胞细胞癌的免疫PET/CT成像与RCCB6:这是第一次对人类进行研究

Qianyun Wu¹, Yanfei Wu², You Zhang¹

¹Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Rd, Shanghai, 200127, China.

European journal of nuclear medicine and molecular imaging

|March 14, 2024

概括

针对CD70的新型免疫oPET/CT标记物显示出清细胞细胞癌 (ccRCC) 检测的前景. 标记物[F]RCCB6有效地识别了患者的ccRCC转移,这表明它有可能改善诊断.

科学领域:

在瘤学瘤学.
核医学是一种核医学.
生物标志物开发生物标志物开发

背景情况:

清细胞细胞癌 (ccRCC) 是一种显著的恶性瘤.
CD70被确定为ccRCC的潜在生物标志物.
需要先进的成像技术来诊断ccRCC和检测转移.

研究的目的:

开发新的CD70向的免疫位子发射断层扫描/计算机断层扫描 (免疫PET/CT) 影像追踪器.
在临床前ccRCC模型中评估这些标记物的诊断价值.
探索这些标记物在检测ccRCC患者转移中的潜力.

主要方法:

四个CD70特异单域抗体 (sdAbs) 经过工程设计,并被放射性标记为F.
在ccRCC患者衍生异种移植 (PDX) 模型中评估了标记物可视化特性.
一项试点临床试验 (NCT06148220) 涉及6名RCC患者接受RCCB6免疫oPET/CT.

主要成果:

开发的标记物专门针对人类CD70而没有与小鼠CD70.0的交叉反应.
[¹⁸F]RCCB6在临床前的ccRCC模型中显示出高的瘤与背景比率.
[F]RCCB6的临床应用成功地可视化了ccRCC转移,并在一名患者身上显示出比F-FDG PET/CT更好的对比.

结论:

成功开发了针对CD70的新型免疫oPET/CT标记剂.
[¹⁸F]RCCB6在临床前的ccRCC检测中表现出高的特异性和有效性.
[¹⁸F]RCCB6的临床翻译表明,识别ccRCC复发和转移有很大的潜力.

关键词:

CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 CD70 免疫性PET是一种PET.分子成像学分子成像学细胞癌是细胞癌.单域抗体是一种单域抗体.

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