Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cellular Differentiation00:57

Cellular Differentiation

2.7K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
2.7K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

2.7K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
2.7K
Cell Migration01:09

Cell Migration

17.0K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.0K
Gastrulation01:56

Gastrulation

57.4K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
57.4K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
1.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Endosteal integrin-α8⁺ mesenchymal stem cells maintain haematopoietic stem cell function via extracellular matrix-mediated interactions.

Nature communications·2026
Same author

The 'Hippocratic Oath' for AI-based clinical decision support systems.

BMC medical informatics and decision making·2026
Same author

Generating crossmodal gene expression from cancer histopathology improves multimodal AI predictions.

Nature communications·2025
Same author

Clinical Phenotypes in Hypertension: A Data-Driven Approach to Risk Stratification.

Hypertension (Dallas, Tex. : 1979)·2025
Same author

Mining higher-order triadic interactions.

Nature communications·2025
Same author

Clinicians must participate in the development of multimodal AI.

EClinicalMedicine·2025

相关实验视频

Updated: Jul 1, 2025

Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns
04:24

Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns

Published on: February 13, 2011

9.6K

用里奇流绘制细胞分化轨迹的图表.

Anthony Baptista1,2, Ben D MacArthur3,4,5, Christopher R S Banerji6,7

  • 1The Alan Turing Institute, The British Library, London, NW1 2DB, UK. abaptista@turing.ac.uk.

Nature communications
|March 14, 2024
PubMed
概括

这项研究介绍了微分几何工具,里奇曲率和流量,以绘制细胞分化图. 这些方法准确地预测基因表达变化,为生物网络重新连接提供了新的见解.

更多相关视频

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

12.6K
Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes
07:13

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

2.2K

相关实验视频

Last Updated: Jul 1, 2025

Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns
04:24

Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns

Published on: February 13, 2011

9.6K
Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

12.6K
Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes
07:13

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

2.2K

科学领域:

  • 计算生物学 计算生物学
  • 系统生物学 系统生物学
  • 不同几何学微分几何学

背景情况:

  • 细胞分化涉及复杂的细胞内信号网络重新布线.
  • 增加的网络与较少分化和恶性细胞状态有关.
  • 之前的工作是连接网络和里奇曲率,将离散曲率应用于生物网络.

研究的目的:

  • 应用里奇曲率和里奇流量来理解和预测细胞分化期间的生物网络重新连接.
  • 为了研究网络和福曼-里奇曲率之间的关系.
  • 为动态生物网络分析开发微分几何工具包.

主要方法:

  • 使用单细胞RNA测序数据对网络和福曼-里奇曲率的理论和实证研究.
  • 应用里奇流来推导网络重新布线轨迹.
  • 基因表达时间课程的分析.

主要成果:

  • 网络和福曼-里奇曲率并不总是正相关,并提供互补的信息.
  • 里奇流准确地预测细胞分化期间基因表达的中间时间点.
  • 这项研究建立了一种新的方法来建模动态生物网络.

结论:

  • 不同几何学,特别是里奇曲率和流量,为分析动态生物网络重新布线提供了强大的工具包.
  • 这种方法提高了我们对细胞分化和癌症的理解.
  • 这些发现挑战了以前关于网络和曲率之间的关系的假设.