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Updated: Jul 1, 2025

Identification of Footprints of RNA:Protein Complexes via RNA Immunoprecipitation in Tandem Followed by Sequencing RIPiT-Seq
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Published on: July 10, 2019

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含有托尔/介质素-1受体 (TIR) 域的蛋白质具有NAD-RNA分解活性

Xufeng Wang1,2,3, Dongli Yu4,5,6, Jiancheng Yu7

  • 1State Key Laboratory for Protein and Plant Gene Research, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking University, Beijing, 100871, China.

Nature communications
|March 14, 2024
PubMed
概括

TIR域蛋白可以从NAD覆盖的RNA (NAD-RNA) 中去除尼古丁胺,产生循环ADPR-RNA. 细菌中的这种deNAMing活动表明TIR蛋白在调节基因表达中的作用.

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