跨物种基因流驱动着Streptococcus pyogenes和Streptococcus dysgalactiae亚种的持续演变. 它们是equisimilis equisimilis
Ouli Xie1,2, Jacqueline M Morris3, Andrew J Hayes3
1Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Nature communications
|March 14, 2024
概括
对Streptococcus dysgalactiae亚种的基因组分析. (SDSE) 显示与Streptococcus pyogenes有显著的重叠,包括共享的基因和移动遗传元素. 这表明疾病监测和开发针对这两种病原体的有效疫苗的含义.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 传染性疾病 传染性疾病
背景情况:
- 链球杆菌dysgalactiae亚种. 脊髓灰质炎 (SDSE) 是一种新兴的病原体,导致侵入性感染.
- SDSE与Streptococcus pyogenes具有临床和流行病学上的相似之处.
研究的目的:
- 为了研究SDSE和S. pyogenes之间的基因组关系.
- 评估这些物种之间的交叉保护和疫苗规避潜力.
主要方法:
- 对501种传播的SDSE菌株进行了系统的基因组分析.
- 用S. pyogenes进行比较基因组分析.
- 识别共享的基因,移动的遗传元素和重组事件.
主要成果:
- 在SDSE和S. pyogenes之间观察到广泛的基因组重叠,超过75%的核心基因共享.
- 在三分之一的共享基因中,有跨物种重组的证据.
- 在物种之间大量共享移动遗传元素和插入区域.
- 在34个S. pyogenes疫苗抗原基因中,12个存在于SDSE和S. pyogenes分离物的99%以上.
- 六个疫苗候选基因显示了物种间重组的证据.
结论:
- SDSE和S. pyogenes表现出大量的基因组重叠,挑战了不同的病原体分类.
- 共享的遗传元素和重组会影响链球菌病理生物学和宿主-病原体相互作用.
- 这些发现对链球菌病监测和广泛疫苗的开发有重大影响.
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