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Updated: May 5, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
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针对人类乳头瘤病毒18型E7的HLAII类受限制的TCR诱导了小鼠的固体瘤缓解

Jianting Long1, Xihe Chen2, Mian He3

  • 1Department of Oncology, Cancer Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.

Nature communications
|March 14, 2024
PubMed
概括

研究人员发现了一种新的T细胞受体 (TCR),向宫癌中的HPV18. 这种TCR在临床前模型中显示出强大的抗瘤活性,目前正在HPV18阳性癌症的I期临床试验中.

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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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