阻塞性睡眠呼吸暂停患者耐性高血压的风险预测名图
Hongze Lin1,2, Chen Zhou1,2, Jiaying Li1,2
1Department of General Practice, The Yixing Hospital affiliated to Jiangsu University, Yixing, 214200, China.
Scientific reports
|March 14, 2024
概括
一种新的名图可以识别患有阻塞性睡眠呼吸暂停 (OSA) 的患者,这些患者有耐性高血压 (RH) 的高风险. 该工具有助于对OSA患者进行个性化管理,可能减少心血管事件.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 医疗信息学 医疗信息学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与耐性高血压 (RH) 和不良心血管结果有关.
- 在OSA患者中预测RH易感性对于主动管理和改善患者预后至关重要.
研究的目的:
- 开发和验证一个预测模型 (nomogram) 用于识别高风险患RH的OSA患者.
- 在OSA群体中确定与RH相关的独立风险因素.
主要方法:
- 从2018年1月到2022年12月使用OSA患者 (n=798) 的临床数据进行了回顾性研究.
- 数据分为培训 (n=539) 和验证 (n=259) 集.
- 单变量分析和LASSO逻辑回归确定了独立的风险因素;构建并验证了一个名图.
主要成果:
- 在OSA患者中确定了五个独立的RH风险因素:吸烟,心脏病,子周长,呼吸暂停-呼吸暂停指数 (AHI) 和T90.0.
- 在培训和验证套件中,开发的名录表显示出良好的区分和校准.
- 决策曲线分析证实了名谱对大多数OSA患者的临床实用性.
结论:
- 建立的诺米图有效地识别了高风险的RH的OSA患者.
- 这种工具可以为OSA患者提供个性化的管理策略,潜在地减轻心血管风险.
- 进一步的临床应用这个名图可能会改善患者在治疗并发性OSA和RH方面的结果.
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