肝纤维化查:从结肠直肠癌和肺癌查中吸取教训
Maja Thiele1,2, Patrick S Kamath3, Isabel Graupera4,5,6,7
1Centre for Liver Research, Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark.
Nature reviews. Gastroenterology & hepatology
|March 14, 2024
概括
广泛的癌症查存在,但肝纤维化查缺乏,尽管患病率和死亡率很高. 这一观点探讨建立肝纤维化查计划,以减少肝病死亡.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 预防医学 预防医学
背景情况:
- 针对结直肠癌和肺癌等癌症的人口查计划是常见的.
- 肝硬化是一种肝病,比结直肠癌更为普遍,死亡率与肺癌相似.
- 目前,对于早期检测肝纤维化,肝硬化的前身,还没有有组织的查计划.
研究的目的:
- 探索肝纤维化查计划的好处,挑战和实施策略.
- 与成功的癌症查计划进行并行比较.
- 为了确定未来肝纤维化查的途径.
主要方法:
- 审查现有的非侵入性肝纤维化识别方法.
- 分析已建立的癌症查计划的见解.
- 讨论成本效益和降低死亡率作为查有效性的关键指标.
主要成果:
- 现有非侵入性方法和转诊途径可用于检测肝纤维化.
- 查计划必须具有成本效益,并且可以明显减少与肝脏相关的死亡率.
- 随机对照试验是必要的,以验证肝纤维化查的好处.
结论:
- 肝纤维化查有可能减少肝硬化负担.
- 成功实施需要来自随机对照试验的强有力的证据.
- 未来的试验应评估查测试和疾病进展的干预措施.
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