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Updated: Jul 1, 2025

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AIRE依靠Z-DNA标记T细胞耐受性的基因目标

Yuan Fang1,2, Kushagra Bansal3, Sara Mostafavi4,5

  • 1Department of Immunology, Harvard Medical School, Boston, MA, USA.

Nature
|March 14, 2024
PubMed
概括

自免疫调节蛋白 (AIRE) 通过识别Z-DNA和NFE2-MAF动机来准基因,这些动机促进DNA双链断裂和平衡促进体. 这种机制通过引导AIRE来提高T细胞的耐受性.

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