在精神分裂症中使用规范建模来描述thalamic核的寿命发展和thalamic核异常的特征
Anna S Huang1, Kaidi Kang2, Simon Vandekar2
1Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. anna.s.huang@vumc.org.
概括
乳头核体积显示了整个生命周期的多样化发育轨迹. 在一些精神分裂症患者中,规范模型确定了特定的thalamic体积偏差,与认知障碍严重程度相关.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 精神病学是一个精神病学.
背景情况:
- 胸膜异常与精神分裂症和神经发育障碍有关.
- 了解胸膜发育及其认知关联是至关重要的.
- 胸膜体积的个体差异对个性化医学构成挑战.
研究的目的:
- 描述整个生命周期的乳头核发育情况.
- 在精神分裂症患者中识别thalamic体积偏差.
- 探讨在精神分裂症患者的乳头体积和认知功能之间的关系.
主要方法:
- 利用了来自人类连接体项目的寿命数据集 (年龄为5-100+) 的规范模型.
- 将这些模型应用于一个独立的精神分裂症患者队列 (17-61岁).
- 分析了与年龄相关的变化和胸膜体积偏差的频率.
主要成果:
- 在thalamic核发育中观察到不同的非线性年龄效应.
- 协会核在年轻人和老年人中表现出负面的年龄影响;感觉运动核在老年人中保持稳定.
- 高达18%的精神分裂症患者表现出异常小的中脊和脊体积.
- 偏差的大小,而不是原始体积,与认知障碍严重程度相关.
结论:
- 规范性建模揭示了整个生命周期的复杂的胸膜发育.
- 一小部分精神分裂症患者表现出显著的胸膜体积减少.
- 识别这些人是迈向精神分裂症精准医学的关键一步.
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