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衰老的微环境损害了CD4⁺ T毛囊辅助细胞分化中的BCL6和CD40L诱导

Jacob S Fisher¹, Irene Adán-Barrientos², Naveen R Kumar^1,3

¹Department of Immunology, Mayo Clinic, Scottsdale, Arizona, USA.

|March 14, 2024

概括

衰老会损害免疫系统,削弱生殖中心的反应和疫苗的有效性. 老年小鼠显示B细胞扩张和抗体产生减少,T毛囊辅助细胞 (Tfh) 功能改变,影响免疫力.

科学领域:

免疫学免疫学免疫学
衰老研究研究衰老研究

背景情况:

衰老的免疫系统表现出衰弱的生殖中心 (GC) 反应,导致免疫力和疫苗有效性降低.
B细胞和CD4+T细胞之间的相互作用的质量,对于GC形成和T毛囊辅助细胞 (Tfh) 分化至关重要,在衰老中了解得很少.

研究的目的:

研究老化如何影响B细胞和CD4+T细胞相互作用的质量.
确定淋巴细胞微环境在与年龄相关的Tfh细胞分化和GC反应中的作用.

主要方法:

在老年和年轻小鼠的免疫.
在体外T细胞激活试验.
通过收养将年轻细胞转移到老年宿主中,然后进行免疫接种.

主要成果:

老年小鼠显示抗原特异性GC B细胞扩张减少,抗体标位降低,并积累了具有BCL6和CD40L表达受损的Tfh细胞.
年龄较大的CD4+T细胞显示CD40L表达减少,而年龄较大的抗原呈现细胞则影响了年轻T细胞的激活.
通过收养将年轻细胞转移到老年宿主中显示出减少扩张和分化为GCB细胞和Tfh细胞,具有改变的Tfh细胞表型.

结论:

衰老对CD4+T细胞和B细胞相互作用的质量产生负面影响,影响Tfh细胞的分化.
老年人中的淋巴状微环境在调节CD4+T细胞分化方面发挥着关键作用.
这些与年龄相关的变化导致生殖中心的建立和维护受损,损害了适应性免疫力.

关键词:

在T毛囊辅助细胞中.老化的老化衰老的老化发芽中心的发芽中心.

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