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透率进入角层层:用于评估皮肤屏障功能的新型定量指标
Suji Yoo1, Jongwook Kim1, Eui Taek Jeong1
1R&D Center, LG H&H Co., Ltd., Seoul, South Korea.
概括
这项研究开发了一种新的非侵入性方法,通过测量光素盐的透度来评估皮肤的外内屏障功能. 这种方法可视化地表示皮肤屏障状况及其治疗后的恢复.
科学领域:
- 皮肤病学 皮肤病学
- 皮肤屏障生理学皮肤屏障生理学
- 生物物理学的生物物理.
背景情况:
- 角层 (SC) 对于皮肤的双向屏障功能至关重要.
- 皮肤间的水损失 (TEWL) 仅测量了内外屏障.
- 需要一种方法来评估外部-内部屏障的功能.
研究的目的:
- 建立一种非侵入性方法来定量评估外内皮肤屏障功能.
- 为了在视觉上呈现一个皮肤屏障模型.
- 评估屏障在恢复皮肤屏障功能的有效性.
主要方法:
- 在人类参与者身上使用二甲基硫酸盐诱导的皮肤屏障损伤.
- 通过使用TEWL和光素盐透来评估SC屏障.
- 通过带剥离和光显微镜评估透率.
主要成果:
- 光素透率随着皮肤屏障损伤而有显著变化.
- 透率显示,在多次带剥离回合后,与TEWL的相关性更强.
- 屏障膏的应用在5天后显著改善了透率.
结论:
- 光素透率是皮肤屏障状况的可靠指标.
- 这种方法提供了定量数据和皮肤屏障状态的视觉表示.
- 开发的方法可以评估皮肤屏障功能和恢复.
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