被震惊的运动员中广泛的白质异常被7T扩散磁共振成像检测到
Anna Gard1, Evgenios N Kornaropoulos2, Maria Portonova Wernersson3
1Department of Clinical Sciences Lund, Neurosurgery, Neurology, Lund University, Lund, Sweden.
Journal of neurotrauma
|March 14, 2024
概括
运动员有持续的脑震荡后症状,在高级神经成像上显示广泛的白质变化. 扩散曲解成像显示出比扩散张力成像更多的异常,与轴突损伤标记相关.
科学领域:
- 神经科学是一个神经科学.
- 运动医学 运动医学
- 放射学 放射学是一门学科.
背景情况:
- 运动相关的脑震荡会导致持续的脑震荡后症状 (PPCS) 和白质损伤.
- 了解PPCS的神经生物学基础对于有效管理至关重要.
研究的目的:
- 通过先进的神经成像和脑脊液 (CSF) 生物标志物,研究PPCS运动员的神经认知障碍和白质异常.
- 为了比较扩散张力成像 (DTI) 和扩散曲解成像 (DKI) 在检测这些变化的灵敏度.
主要方法:
- 22名PPCS运动员和22名对照运动员的队列接受了7TMRI (包括DTI和DKI),神经心理测试和CSF采样.
- 分析的重点是白质管道的完整性,神经认知性能,以及像神经丝光 (NfL) 这样的CSF生物标志物.
主要成果:
- 与对照人群相比,患有PPCS的运动员表现出显著的神经认知缺陷.
- 虽然大脑总体积相似,但在脑震荡运动员中,28%的扩散指标 (更多来自DKI而不是DTI) 显著改变.
- 在PPCS组中观察到增加的DKI分数异构和轴性形,与辐射扩散率和形的降低.
结论:
- 在患有PPCS的运动员中,广泛的白质微观结构变化仍然存在,可以通过先进的神经成像检测到.
- 在识别这些变化时,DKI指标比DTI更敏感.
- 观察到的白质变化与轴突损伤标记相关,表明脑震荡后正在进行的病理生理过程.
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