在紧急高血压中,生物标志物可以改变指南吗?
Mohammad El Tahlawi1, Scopus Mohamed Ismail2,3, Ahmed Eldamanhory2
1Zagazig University Hospitals, Zagazig, Egypt. tahlawi_basha@yahoo.com.
BMC cardiovascular disorders
|March 14, 2024
概括
在严重的高血压中,高高灵敏度的热素T (hs-TNT) 的升高表明损伤和死亡的风险更高. 在积极降低血压之前评估生物标志物对于管理高血压紧急情况至关重要.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 关键护理医学 关键护理医学
背景情况:
- 高血压可能导致目标器官损伤 (TOD).
- 标准血压 (BP) 管理可能并不适用于所有高血压疾病.
- 脏TOD是严重高血压的一个重要问题.
研究的目的:
- 评估针对性高血压管理对严重高血压中 TOD 的影响.
- 评估高灵敏度托宁T (hs-TNT) 在预测严重高血压中结局中的作用.
主要方法:
- 对470名入住ICU的重度高血压 (BP>180/120 mmHg) 患者进行前性队列研究.
- 患者按照指导方针接受了目标血压治疗.
- 在入院和24小时后测量hs-TNT和血清肌素 (s.creat);根据初始hs-TNT水平分成组.
主要成果:
- 与正常hs-TNT (A组) 患者相比,最初高hs-TNT (B组) 患者的住院死亡率和 TOD (急性功能障碍) 显着更高.
- 与A组不同的是,B组在24小时内显示出液水平的显著增加,而A组则在24小时内显著增加.
- 在hs-TNT和随访s.creat.之间发现了显著的正相关性.
结论:
- 严重高血压时hs-TNT升高可能表明功能衰竭和死亡风险增加,特别是在积极降低血压时.
- Hs-TNT可以作为一种有价值的生物标志物,用于严重或紧急高血压患者的风险分层.
- 在紧急高血压管理中实施基于指南的BP目标之前,应考虑生物标志物评估.
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