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在双边肺移植之前的格拉姆阴性细菌殖民. "有针对性的"与"标准的"外科预防的影响

Sabrina Congedi¹, Arianna Peralta², Luisa Muraro²

¹Department of Medicine (DIMED), University of Padua, Padua, Italy.

BMC infectious diseases

|March 14, 2024

概括

向预防并没有在已经被这些细菌殖民的患者中预防肺移植 (LT) 后的格拉姆阴性感染. 这项研究表明,标准预防可能在减少术后多药耐药性感染方面同样有效.

科学领域:

传染性疾病传染性疾病
移植手术移植手术
抗微生物药物管理委员会

背景情况:

感染是肺移植 (LT) 后死亡的主要原因.
在LT接受者中,针对格拉姆阴性 (GN) 细菌殖民的向抗菌预防的有效性仍然不确定.

研究的目的:

评估与标准预防相比,针对性抗微生物预防在预防手术后的格兰氏阴性细菌感染的有效性,在肺部移植接受者与先前存在的GN殖民.

主要方法:

在帕多瓦大学医院 (2016-2023) 的双边LT接受者的回顾性分析.
具有先前存在的GN细菌分离的患者被分为"标准"和"向"的抗微生物预防组.
评估的结果包括术后多药耐药性 (MDR) GN细菌的隔离和感染率.

主要成果:

在46名登记的LT接受者中,22人接受了向和24人接受了标准预防.
在65%的患者中发生了MDR GN细菌的术后隔离,预防组之间没有显著差异 (p=0.364).
由于MDR GN细菌造成的术后感染的患病率为50%,在向预防组 (11对4名患者,p=0.027) 的患病率显著更高.

结论:

在具有先前存在GN殖民的LT接受者中,有针对性的预防似乎无法预防手术后的MDRGN感染.
研究结果表明,在这种患者群体中,标准预防可能与向预防同等或更有效.

关键词:

抗生素抗生素是一种抗生素.抗微生物药物管理管理双边的肺移植.肺移植是什么意思?肺移植是什么意思预防预防预防进行手术预防.

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