肝移植后使用双酸盐的患者的骨格模式变化
Marcus Vinícius Bueno1, Luciana Munhoz2, Karem L Ortega3,4
1Department of Dentistry, Central Institute, Clinical Hospital of Medical School of the University of São Paulo, São Paulo, SP, Brazil.
概括
接受双酸盐的肝移植患者表现出更多的骨硬化症,增加了骨缩的风险和骨矿物质密度降低. 这项研究强调了这些患者的放射性变化.
科学领域:
- 口腔和面放射学 口腔和面放射学
- 移植医学 移植医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 双酸盐通常用于管理肝移植接受者的骨密度损失.
- 骨瘤 (ONJ) 是与双酸盐使用相关的潜在并发症.
- 放射性评估可以帮助识别骨变化的早期迹象.
研究的目的:
- 在肝移植患者中识别药物诱导骨髓缩的放射性指标.
- 评估与这些患者骨矿物质密度变化相关的放射形态测量模式.
- 评估双酸盐使用与放射性发现之间的关联.
主要方法:
- 分析了使用双酸盐 (研究组) 和不使用双酸盐 (对照组) 的肝移植患者的全景放射图.
- 评估的放射性参数包括精神指数 (MI),下皮质指数 (MCI) 和骨硬化的迹象.
- 统计分析比较了有关骨矿物质密度 (BMD) 和双酸盐使用的组.
主要成果:
- 骨矿物质密度 (BMD) 的统计学显著下降与MCI-C3相关 (p=0.036).
- 没有发现MI与BMD相关的显著统计结果 (p=0.14).
- 没有有效的统计结果将MCI或MI与减少的BMD和双酸盐使用联系起来.
结论:
- 接受双酸盐肝移植的肝脏移植患者表现出骨质硬化症的放射性征兆增加,这表明他们更容易患上骨.
- 这些患者在全景放射图上也显示了骨矿物质密度变化降低的风险增加.
- 放射性监测对于早期检测肝移植接受者服用双酸盐的这些并发症至关重要.
关键词:
双酸盐相关的骨瘤肝移植 肝移植 肝移植器官移植器官移植器官移植器官移植骨质疏松症是一种骨质疏松症.全景射线图 (Panoramic Radiography) 是一个全景射线图.辐射学 放射学 辐射学更多相关视频
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