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Updated: Aug 8, 2026

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models
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Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models

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对谷氨酸释放的光学测量可靠地报告了快速中央突触的短期可塑性

Paul Jakob Habakuk Hain1,2, Tobias Moser1,2

  • 1Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.

Frontiers in molecular neuroscience
|March 14, 2024
PubMed
概括

像iGluSnFR这样的光学传感器可以测量突触中的谷氨酸释放,从而提供关于突触前功能的见解. 这项研究验证了它们在赫尔德突触的末泡中的使用,以评估突触可塑性.

关键词:
通过AAV介导的基因转移.举办的终端灯泡.谷氨酸的成像成像学补丁电生理学 补丁电生理学突触性可塑性 突触性可塑性

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Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis08:59

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相关概念视频

Plastic Behavior01:21

Plastic Behavior

A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and reloaded.