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短肠综合征中的循环氧酸盐水平作为CKD的严重性标志物

Christophe Grocholski¹, Cécile Chambrier², Madeleine Lauverjat²

¹Nephrology, Dialysis, Hypertension and Functional Renal Explorations, Hôpital Edouard Herriot, Hospices Civils de Lyon, France.

Kidney international reports

|March 14, 2024

概括

短肠综合征 (SBS) 患者可能会产生高血氧酸盐 (POx) 水平,增加慢性病 (CKD) 风险. 这项研究探讨了POx分布,在相当一部分SBS患者中发现了高水平,突出了肠道高氧化症 (EH) 的潜在生物标志物.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
胃肠病学胃肠病学
代谢障碍代谢障碍代谢障碍

背景情况:

短肠综合征 (SBS) 与肠道高氧化尿 (EH) 相关,这种情况可能导致氧酸盐脏病.
血中氧酸盐 (POx) 含量是系统性氧酸盐沉积的标志物,可能表明慢性病 (CKD) 的风险增加.
在SBS患者中升高POx的患病率和影响尚未完全理解.

研究的目的:

在被诊断患有短肠综合征 (SBS) 的患者中研究血氧沙酸盐 (POx) 水平的分布.
评估SBS患者的POx水平,尿液中氧酸盐分泌和功能之间的关系.
探索POx作为生物标志物的潜力,以评估肠道高氧化尿 (EH) 的严重程度.

主要方法:

预期招募SBS患者 (2型和3型,持续时间>6个月) 参与OXAGO研究 (NCT04119765).
在每年脏随访期间评估血氧沙酸 (POx) 和iohexol清除剂的球过率 (GFR).
在研究队列中测量24小时尿液中酸盐 (UOx) 排泄量.

主要成果:

在45名被评估的患者中,29%的POx水平≥5μmol/l.
与正常POx (NPO) 患者相比,高POx (HPO) 患者的24小时尿液氧酸盐 (UOx) 含量显著增加 (919对526μmol/l;P=0.003).
与NPO组相比,HPO组的平均GFR (49毫升/分钟/1.73米2) 显著较低 (73毫升/分钟/1.73米2;P=0.0005),其中91%的总队列患有CKD.

结论:

短肠综合征患者可以呈现血氧沙酸盐 (POx) 水平升高,即使膜过率 (GFR) 超过30毫升/分钟/1.73米2.
血中氧酸盐 (POx) 可能作为一个有价值的生物标志物来评估SBS患者肠道高氧流症 (EH) 的严重程度.
这些发现强调了监测SBS患者的POx的重要性,以确定病进展的风险.

关键词:

肠道高氧化尿的发生.血中氧酸盐的含量是多少短肠短肠是一个短肠.

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