上部胃肠道出血中的特兰克萨姆酸与静脉和动脉血栓栓事件有关
Cosmo Fowler1, Jason Nasser2, Brittany Fera1
1Department of Anesthesiology and Critical Care Medicine, Critical Care Center, Memorial Sloan Kettering Cancer Center, New York, NY.
Critical care explorations
|March 14, 2024
概括
在上部胃肠道出血 (UGIB) 患者中使用特兰胺酸与静脉和动脉血栓栓塞事件的风险增加有关. 需要进一步的研究,以澄清在管理UGIB中使用特兰胺酸的风险-益处概况.
科学领域:
- 医学研究 医学研究
- 临床药理学 临床药理学
- 血栓形成和血液静止.
背景情况:
- 上部胃肠道出血 (UGIB) 是一个重大的临床挑战.
- 特兰胺酸用于减少出血,但其对血栓栓塞事件的安全性需要进一步调查.
研究的目的:
- 为了比较 UGIB 患者的动脉和静脉血栓栓塞事件的风险,这些患者接受过特兰胺酸,而不是那些没有接受过特兰胺酸的人.
- 评估特兰胺酸和UGIB患者不良血栓结局之间的关联.
主要方法:
- 使用TriNetX研究网络数据库 (超过1.1亿患者) 的回顾性队列研究.
- 包括2,016,763名在2003年至2023年期间被诊断患有血或黑色素的患者.
- 倾向性得分匹配用于控制对结果进行比较时的混因素.
主要成果:
- 接受特兰胺酸的患者患心肌梗塞 (OR 1.4),脑血管事故 (OR 1.6),肺栓塞 (OR 1.8) 和深静脉血栓塞 (OR 2.1) 的发生率明显较高.
- 所有观察到的血栓栓塞事件的增加均具有统计学意义 (p < 0.001).
结论:
- 在UGIB患者中使用特兰胺酸与增加静脉和动脉血栓栓塞事件的风险之间存在相关性.
- 与动脉事件的关联是一个新发现,突出显示需要前性研究,以充分了解在UGIB管理中西胺酸的风险-益处.
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