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Denis J Vanini1, Jenna M Corvelli1, Kaylee M Maynard1
1Department of Pharmacy, University of Rochester Medical Center, Rochester, NY.
Critical care explorations
|March 14, 2024
概括
在重症监护室,对患有阿片类药物使用障碍 (OUD) 的重症患者来说,布普伦诺芬是安全的. 低剂量诱导策略显著降低了阿片类药物需求,证明了其在这个人群中的有效性和安全性.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 成 药物 药物 药物 药物
背景情况:
- 布普伦诺芬越来越多地用于阿片类药物使用障碍 (OUD),但其在重症监护室 (ICU) 的应用没有充分记录.
- 关于重症患者使用布普伦诺芬的文献有限.
研究的目的:
- 描述ICU团队之间的布普伦诺芬处方实践.
- 评估一种新的低剂量启动策略,用于ICU中的布普伦诺芬.
- 评估急性戒断的发生率和阿片类药物需求的变化.
主要方法:
- 进行了一项单一中心,回顾性,描述性研究.
- 收集的数据包括布普伦诺芬的指示,启动策略,剂量和时间.
- 在低剂量诱导策略之前和之后,分析了阿片类药物需求和急性戒断发生率.
主要成果:
- 153名患者在ICU接受了布普伦诺芬治疗,主要是OUD (86.3%).
- 一种低剂量诱导策略 (n=38) 导致完全激动性阿片类药物MME (1057.5至262.5,p < 0.005) 的显著减少.
- 标准和低剂量诱导策略都表明,急性戒断的发生率很低 (一个实例).
结论:
- 舌下布普伦诺芬主要用于ICU中的OUD.
- 在ICU中继续使用家庭布普伦诺芬是不理想的.
- 低剂量布普伦诺芬诱导是一种安全有效的策略,可以减少重症患者的阿片类药物需求.
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