传单 跨导管大动脉门不同设计和不同世代的机械应力:一个体外研究
Viktória Stanová1,2, Régis Rieu1, Lionel Thollon1
1Aix-Marseille University/Gustave Eiffel University, LBA-UMRT24, Marseille, France.
Structural heart : the journal of the Heart Team
|March 14, 2024
概括
较新的透管心脏门 (THV) 与老一代相比,显示了减少的传单压力. 自扩展 (SE) THV的机械应力低于气球可扩展 (BE) THV,可能提高长期耐用性.
科学领域:
- 心血管工程 心血管工程
- 生物材料科学 生物材料科学
- 医疗器械设计 医疗器械设计
背景情况:
- 在跨导管大动脉植入 (TAVI) 中,生物假体的长期耐用性仍然不确定.
- 门叶片的重复性机械应力,特别是在腹痛期间,导致结构门的恶化.
- 在体内测量传单机械应力是不可能的.
研究的目的:
- 为了比较旧与新一代自扩展 (SE) 和气球可扩展 (BE) 跨导管心脏门 (THV) 的传单机械应力.
- 评估不同THV设计中的传单机械应力的大小和区域分布.
主要方法:
- 使用双激活模拟器进行体外试验,使用两代SE和BETHV.
- 立体摄影测量和数字图像相关性,用于高分辨率的3D运动分析.
- 基于实验变形数据的有限元建模,计算在透气过程中的局部传单机械应力.
主要成果:
- 在早期与新THV代相比,最大的传单压力显著更高 (p < 0.05).
- 气球可扩展 (BE) THV 呈现的压力比自扩展 (SE) THV 跨代更高 (p < 0.05).
- 最高的应激度发生在指导部附近和中叶体内,与体内恶化部位相关.
结论:
- 新一代THV的机械应力大约比以前的机械应力低30%.
- 自扩展式 (SE) THV 总是比气球可扩展式 (BE) THV 显示较低的传单应力.
- 需要进一步的研究来确认这些机械差异是否会改善体内长期耐用性.
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