多种多种直接养微生物在生长的母牛模型中在料限制期间对胃肠道通透性的影响
B M Goetz1, M A Abeyta1, S Rodriguez-Jimenez1
1Department of Animal Science, Iowa State University, Ames, IA 50011.
JDS communications
|March 14, 2024
概括
直接养的微生物 (DFM) 在料限制期间没有改善牛的胃肠道 (GIT) 透性或炎症. 料限制对母牛的新陈代谢和免疫状况产生了负面影响,不论是对DFM的补充.
科学领域:
- 动物科学动物科学
- 类动物营养 类动物营养
- 胃肠道生理学 胃肠道生理学
背景情况:
- 牛的料限制 (FR) 可能会对胃肠道 (GIT) 屏障功能产生负面影响,并诱导炎症.
- 直接养微生物 (DFM) 被建议调节肠道健康,但它们在营养压力期间的有效性需要进一步研究.
- 了解DFM在FR期间对GIT完整性的影响,对于优化牛的健康和表现至关重要.
研究的目的:
- 评估4个菌株直接养微生物 (DFM) 对胃肠道 (GIT) 透性和炎症对受料限制 (FR) 的公牛的影响.
- 评估对FR和DFM补充剂的代谢和免疫反应.
- 确定DFM是否可以减轻FR对GIT屏障功能的负面影响.
主要方法:
- 32只荷尔斯坦公牛被分配给对照饮食或补充4个菌株DFM (Lactobacillus animalis,Propionibacterium freudenreichii,Bacillus licheniformis,Bacillus subtilis) 的饮食.
- 雌牛经历了14天的基线期 (P1),随后是5天的料限制期 (P2),其中干物质摄入量减少到P1.0的40%.
- 使用口服 (Cr) -EDTA评估了胃肠道的透性,并分析了血液样本以检测代谢和炎症标志物.
主要成果:
- 在所有母牛中,限制料显著降低了干物质摄入量和体重.
- FR诱导的代谢变化,包括降低葡萄糖和胰岛素,增加非化脂肪酸和哈普托格洛宾,不管DFM治疗.
- 虽然FR增加了GIT透性 (血CrAUC) 和炎症标志物 (血清粉样蛋白A,哈普托格洛宾,IFN-γ诱导蛋白-10),但4菌株DFM并没有显著改变这些反应.
结论:
- 限制料损害了胃肠道屏障功能,并刺激了小牛的全身炎症反应.
- 用测试的4个菌株直接养的微生物补充剂并没有改善料限制对GIT透性或炎症的负面影响.
- 需要进一步的研究来探索替代的DFM配方或策略,以支持在牛的营养挑战期间的肠道健康.
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