向有控制释放的药物输送 微型载体由直接激光写作3D打印启用
Sunandita Sarker1, Kimia Forghani1, Ziteng Wen1
1Department of Mechanical Engineering, University of Maryland, College Park, MD, USA.
Proceedings. IEEE International Conference on Micro Electro Mechanical Systems
|March 14, 2024
概括
研究人员开发了可生物降解的3D打印微载体,用于控制药物输送. 使用双光子直接激光写作,他们创建了液体核心外盖设备,盖子随着时间的推移降解,释放药物.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 添加剂制造 添加剂制造 添加剂制造
背景情况:
- 控制释放药物递送系统对于有效的医疗治疗至关重要.
- 之前的工作展示了基于光电阻的液体芯盖微载体的3D打印.
- 生物降解材料为先进的药物输送解决方案提供了一个有前途的途径.
研究的目的:
- 探索可生物降解材料在3D打印的微载体中用于控制药物释放的使用.
- 通过双光子直接激光写字 (DLW) 来研究使用可生物降解的聚合物制造液体核心外盖微载体的制造.
- 评估DLW3D打印在创建新型药物输送系统方面的潜力.
主要方法:
- 使用双光子直接激光写作 (DLW) 进行3D打印微载体.
- 制造的微载体具有瓶形外,水性液体核心和可生物降解的盖子.
- 采用聚乙烯甘二烯酸盐 (PEGDA) 作为可生物降解的盖子材料.
主要成果:
- 成功地3D打印了带有可生物降解PEGDA盖的微载体.
- 证明了具有微流体阻塞结构的外设计可以在盖子打印过程中防止液体核心污染.
- 在盖子制造后实现了液体核心的更好的保留.
结论:
- DLW 3D打印策略是制造可生物降解的微载体用于药物输送的可行方法.
- 开发的微载体系统显示出控制释放应用的潜力.
- 需要进一步评估,以评估这种3D打印方法在药物输送中的实用性.
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