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深度大脑刺激不会调节基本震中的休息状态功能连接.

Amar Awad1,2, Filip Grill1,3, Patric Blomstedt4

  • 1Umeå Center for Functional Brain Imaging (UFBI), Umeå University, 90187 Umeå, Sweden.

Brain communications
|March 14, 2024
PubMed
概括

对于基本震而言,深度大脑刺激不会改变静止状态的大脑连接. 这表明,治疗治疗.

关键词:
尾部区域不确定深度大脑刺激 刺激大脑基本震是一种基本的震.功能连接性的功能连接性静止状态的fMRI进行.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 医疗成像医学成像

背景情况:

  • 基本震 (ET) 是一种神经疾病,其特征是动作诱导的震.
  • 在ET中深度大脑刺激 (DBS) 功效背后的精确机制仍然难以捉摸.
  • 人们假设大脑-丘脑-大脑电路的功能障碍驱动ET症状.

研究的目的:

  • 研究DBS对ET患者休息状态功能连接性的影响.
  • 为了确定DBS是否在休息时调节神经网络活动.
  • 探索DBS效应与大脑 - 丘脑 - 大脑电路之间的关系.

主要方法:

  • 功能磁共振成像 (fMRI) 用于植入DBS的16名ET患者.
  • 在"开启"和"关闭"治疗DBS刺激期间评估了休息状态的功能连接性.
  • 基于种子和数据驱动的方法被用于分析传感器和非传感器区域的连接模式.

主要成果:

  • 深度大脑刺激没有显著调节基本震患者的休息状态功能连接.
  • 在"开启"和"关闭"DBS条件之间没有观察到功能连接的差异.
  • 这一发现与之前在运动任务中观察到的DBS效应形成鲜明对比.

结论:

  • 缺乏对静态连接的影响表明,ET中的DBS调制可能是取决于行动的.
  • 在基本震中,DBS的有效性可能取决于改变与任务相关的网络活动,而不是基线连接.
  • 需要进一步的研究来阐明精确的DBS在本质震中的取决于行动的机制.