对影响局部晚期前列腺癌临床因素的多变量逻辑回归分析
Zongpan Ke1,2, Yan Xu1, Yawei Shu1
1Department of Urology, The First Affiliated Hospital of USTC (the University of Science and Technology of China), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Translational cancer research
|March 14, 2024
概括
体重指数 (BMI) 和前列腺特异性抗原 (PSA) 水平是局部晚期前列腺癌 (PCa) 的关键指标. 识别这些风险因素可以改善PCa患者的诊断和预后.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医学诊断 医学诊断 医学诊断
背景情况:
- 局部晚期前列腺癌 (PCa) 预后不好,在手术后复发和转移风险高.
- 临床因素和全身炎症指标对于评估PCa风险至关重要.
- 病态T阶段是局部发达PCa的主要指标.
研究的目的:
- 确定局部晚期前列腺癌 (PCa) 的独立风险因素.
- 探索临床因素 (如BMI,PSA) 和系统性炎症指标与PCa T阶段之间的关系.
- 为了评估这些因素的诊断准确性,用于PCa分期.
主要方法:
- 对177名病理确认PCa.患者的回顾性分析.
- 斯皮尔曼等级相关性用于识别病理T阶段的相关性.
- 后勤命令多重回归和ROC曲线分析以确定独立的风险因素和诊断准确性.
主要成果:
- 体重指数,PSA水平,格里森得分,高血压,N阶段和M阶段与T阶段显著相关 (P<0.05).
- PSA 水平 (AUC=0.802) 显示PCa T 阶段的诊断值高于BMI (0.675).
- 综合的BMI和PSA改善了诊断准确度 (AUC=0.822).
结论:
- 体重指数 (BMI) 和前列腺特异抗原 (PSA) 是局部发达PCa的独立危险因素.
- 这些因素在本地先进的PCa的发展和进展中发挥着重要作用.
- 结合BMI和PSA可以提高局部发达PCa的诊断能力.
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