用 efavirenz 或 dolutegravir 治疗的严重患有艾滋病的患者的结果:一个多中心的观察性研究
Carlos Brites1, Marcus Lacerda2, Eduardo Sprinz3
1Laboratório de Pesquisa em Infectologia, Department of Medicine, Hospital Universitário Professor Edgard Santos - EBSERH, Federal University of Bahia, Salvador, Brazil.
Frontiers in medicine
|March 14, 2024
概括
与以 efavirenz (EFV) 为基础的疗法相比,基于多卢特格拉维尔 (DTG) 的ART显著改善了晚期艾滋病患者的病毒抑制和治疗耐久性. DTG显示病毒抑制率较高,治疗变化较少,为艾滋病毒感染者提供更好的结果.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 临床药理学 临床药理学
背景情况:
- 基于整合酶抑制剂 (INIs) 的抗逆转录病毒疗法 (ART) 首选用于晚期艾滋病.
- 有限的数据存在于dolutegravir (DTG) 在晚期呈现的艾滋病毒感染者 (PLHIV) 的使用.
研究的目的:
- 为了比较DTG与基于efavirenz (EFV) 的ART疗程的疗效.
- 评估接受DTG或EFV的晚期艾滋病患者的结果.
主要方法:
- 一项对高级艾滋病患者的比较队列研究 (世卫组织4期,CD4<50细胞/毫升).
- 来自巴西五个城市的前性DTG队列 (2018-2021) 和回顾性EFV队列 (2013-2016).
- 终点包括死亡率,24/48周病毒抑制,CD4计数变化和治疗修改.
主要成果:
- 在24周 (67.4%对42.4%) 和48周 (65.2%对45.7%) 中,DTG与EFV的病毒抑制率更高.
- 在48周的DTG组中,CD4计数 (>200细胞/毫升) 的增加较大 (45%对29%).
- 在DTG组的治疗变化显著减少 (1%对17%).
结论:
- 基于DTG的ART在晚期艾滋病患者中显示出卓越的病毒抑制和治疗耐久性.
- 与EFV相比,DTG为这个脆弱人群提供了更好的结果.
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