在没有心血管疾病的成年人中,饮食中酸盐摄入量和骨肌肉能量之间存在关联
John M Giacona1,2, Areeb Afridi1, Ursa Bezan Petric1
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|March 14, 2024
概括
西方饮食中的高酸盐摄入量与人体肌肉能量生产减少和线粒体功能受损有关. 这项研究揭示了潜在的机制,将饮食与能量代谢不良联系起来,影响肌肉性能.
科学领域:
- 人类骨肌肉生理学 人类骨肌肉生理学
- 线粒体功能 线粒体功能
- 通过饮食代谢的代谢.
背景情况:
- 在西方饮食中,高摄入生物可用的无机酸盐 (Pi) 是常见的.
- 过多的饮食Pi已知会导致小鼠的运动不耐受和线粒体功能障碍.
- 饮食中的Pi对人类骨肌肉能量代谢的影响以前是未知的.
研究的目的:
- 研究人类的酸盐摄入量与骨肌肉线粒体功能之间的关联.
- 探索食酸盐,肌肉ATP合成和运动期间的脂蛋白动态之间的关系.
主要方法:
- 13名健康成年人接受了24小时的饮食回忆,以评估酸盐摄入量.
- 使用7-特斯拉31P磁共振光谱法测量休息肌肉ATP合成和运动诱导的乳牛肌中脂蛋白 (PCr) 枯竭.
- 与肌肉能量代谢参数相关的食酸盐摄入量,根据年龄和功能进行调整.
主要成果:
- 较高的酸盐摄入量与较低的静止ATP合成显著相关 (r = -0.62,P = 0.03).
- 增加的酸盐摄入量与运动期间更大的PCr耗尽相关 (r = -0.72,P = 0.004).
- 这些关联在调整年龄和估计的膜过率后仍然存在.
- 饮食中高酸盐与较低的血清Klotho水平有关,这反过来与肌肉能量代谢受损相关.
结论:
- 这项研究提供了人类的第一个直接证据,即更高的酸盐摄入量会损害骨肌肉的线粒体功能.
- 食酸盐与肌肉ATP合成在休息和运动期间的减少有关,独立于年龄和功能.
- 这些发现表明,一种新的生物机制将西方饮食模式与能量代谢受损以及潜在的临床饮食影响联系起来.
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