脑中风中的外周血管功能:系统审查和元分析
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Updated: May 10, 2026

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Non-invasive Assessment of Microvascular and Endothelial Function
Published on: January 29, 2013
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Bria L Bartsch1,2, Emily M Hazen2, Robert N Montgomery3
1Department of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, Kansas, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|March 14, 2024
概括
通过流媒扩张 (FMD) 测量的外周血管功能障碍在中风恢复期间持续存在,增加了未来心血管事件的风险. 这一审查证实了所有中风阶段的口炎受损,强调了血管健康干预的必要性.
科学领域:
- 心血管科学 心血管科学
- 神经学 神经学
- 血管生物学 血管生物学
背景情况:
- 通过流媒扩张 (FMD) 量化的外周血管功能障碍是心血管事件的已知危险因素.
- 在各种心血管疾病中观察到口炎损伤,但其在中风恢复阶段的轨迹需要详细的描述.
研究的目的:
- 系统地审查和元分析个人中风后的FMD基线值.
- 通过急性,亚急性和慢性中风恢复阶段来表征口病.
- 调查年龄和中风后的时间对口病的影响.
主要方法:
- 在PubMed,CINAHL和Embase数据库中进行了系统的搜索,搜索2000年1月1日至2023年10月12日期间发表的研究.
- 三位审查员进行了研究选择,数据提取和质量评估.
- 随机效应模型被用于元分析,元回归检查年龄和时间的中风后效应.
主要成果:
- 包括包括缺血性和出血性中风的28项研究.
- 研究中平均估计的口病为3.9% (95% CI: 2.5-5.3%),具有显著的异质性 (I2 = 99.6%).
- 无论是平均年龄还是中风后的时间都与口病值没有显著的相关性.
结论:
- 周围血管功能障碍,指的是受损的口病,在中风恢复的所有阶段都存在.
- 这种持续的血管功能障碍强调了针对血管健康的干预措施的迫切需要,以改善结果并预防复发性中风.
- 这些发现强调了口病作为评估中风后血管健康的相关生物标志物.
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